Kyrah Thumbadoo
Cyto-Architectural Digest
To understand the processes underlying the cause of disease, we must first understand the cellular environment in which the disease will form. This image demonstrates the diverse number of cell types found within the human hippocampus, a region of the brain which is fundamental for our memory and ability to learn. A technique called multiplex-immunohistochemistry was used to create this image, resulting in each visible colour representing a different specialised cell type in the hippocampus.
The hippocampal region of the brain is regularly affected in ageing, and in specific neurological diseases like dementia and Motor Neuron Disease. The University of Auckland researcher, Miss Thumbadoo, hopes that by correlating the presence of specific cells types with known markers of disease, we can see which cell types are more impacted in disease, how the course of disease spreads, and whether these changes are related to specific genetic mutations. Miss Thumbadoo hopes this knowledge will allow for the development of effective, personalised treatments for neurological conditions affecting this region of the brain.